Risk of relapse after antidepressant discontinuation in anxiety disorders, obsessive-compulsive disorders, and post-traumatic stress disorder
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چکیده
Methods The results of 28 relapse prevention trials, including a total of 5233 patients, were summarised in a meta-analysis. Studies were included if they focused on patients with anxiety disorder who responded to antidepressants, if they randomised patients to either continuing antidepressants or switching to placebo, and if they compared relapse rates or time to relapse between patients who continued antidepressants and patients who discontinued antidepressants.
منابع مشابه
Risk of relapse after antidepressant discontinuation in anxiety disorders, obsessive-compulsive disorder, and post-traumatic stress disorder: systematic review and meta-analysis of relapse prevention trials
During the editing process of this Research paper (BMJ 2017;358:j3927, doi:10.1136/bmj.j3927) the word ‘not’ was omitted from the following sentence in the Discussion (third paragraph): “However, the higher relapse rate in the placebo group is probably attributable to withdrawal symptoms—that is, most of the studies tapered antidepressants thereby diminishing withdrawal symptoms.” This sentence...
متن کاملRisk of relapse after antidepressant discontinuation in anxiety disorders, obsessive-compulsive disorder, and post-traumatic stress disorder: systematic review and meta-analysis of relapse prevention trials
Objectives To examine the risk of relapse and time to relapse after discontinuation of antidepressants in patients with anxiety disorder who responded to antidepressants, and to explore whether relapse risk is related to type of anxiety disorder, type of antidepressant, mode of discontinuation, duration of treatment and follow-up, comorbidity, and allowance of psychotherapy.Design Systematic re...
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تاریخ انتشار 2017